GenomeView is a stand-alone sequence browser specifically designed to visualize and manipulate a multitude of genomics data interactively. GenomeView enables users to dynamically browse high volumes of aligned short read data, with dynamic navigation and semantic zooming, from the whole genome level to the single nucleotide. At the same time, the tool enables visualization of whole genome alignments of dozens of genomes relative to a reference sequence. GenomeView is unique in it capability to interactively handle huge data sets consisting of dozens of aligned genomes, thousands of annotation features and millions of mapped short reads both as viewer and editor.